NewsTakeda Receives Positive CHMP Opinion for Recombinant ADAMTS13 in cTTP

Takeda Receives Positive CHMP Opinion for Recombinant ADAMTS13 in cTTP

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May 31, 2024- Takeda announced that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended the approval, under exceptional circumstances, of recombinant ADAMTS13 (rADAMTS13) for the treatment of ADAMTS13 deficiency in children and adult patients with Congenital Thrombotic Thrombocytopenic Purpura (cTTP). The European Commission (EC) will consider the CHMP positive opinion when determining the potential marketing authorization for rADAMTS13 throughout the EU. If approved, rADAMTS13 will be the first and only enzyme replacement therapy in the EU to treat cTTP.

“People living with cTTP experience serious, potentially fatal health challenges and have limited treatment options in the European Union,” said Obi Umeh, M.D., M.Sc., Vice President, Franchise Global Program Leader at Takeda. “With this positive opinion for recombinant ADAMTS13, we are one step closer to offering patients in the EU the first treatment specifically indicated for cTTP. We look forward to the European Commission’s decision as we aspire to transform the standard of care for cTTP for more patients around the world.”

Also Read: U.S. FDA Approves Subcutaneous Administration of Takeda’s ENTYVIO® (vedolizumab)

Furthermore, cTTP is an ultra-rare, chronic blood clotting disorder caused by a deficiency in the ADAMTS13 enzyme. It is associated with acute events and debilitating chronic symptoms or thrombotic thrombocytopenic purpura (TTP) manifestations, which can include thrombocytopenia, microangiopathic hemolytic anemia, renal manifestations, stroke and abdominal pain. Untreated, acute TTP events have a mortality rate of >90%.

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